PBK在前列腺癌组织中的表达及临床意义

Expression and clinical significance of PBK in prostate cancer tissues

目的分析PBK在前列腺癌中的表达及临床意义。方法利用前列腺癌的组织芯片,包含98例前列腺癌及81例对照癌旁组织作为研究对象,免疫组化方法检测PBK的表达情况,并运用统计学方法分析免疫组化芯片及Taylor数据库中PBK表达与前列腺癌临床病理特征之间的关系。结果 PBK在前列腺癌中表达明显升高(P=0.001);且在Gleason高评分组的表达比低评分组表达升高(P=0.001)。Taylor数据库得到相似结果,且运用Kaplan-Meier分析发现PBK与无生化复发生存率显著相关(P=0.007),最后采用Cox回归模型进行多因素综合分析发现在影响前列腺癌预后的队列中,PBK高表达(P=0.041)与Gleason评分、病理分期都是前列腺癌生化复发的独立预测指标。结论 PBK的表达与前列腺癌密切相关,可作为临床诊断及治疗的分子标志物。

Objective To investigate the expression and clinical significance of PBK in prostate cancer. Methods Using tissue microarrays of prostate cancer,which including 98 cases of prostate cancer and 81 cases of normal tissue adjacent to cancer as the research object,the expression of PBK was detected by immunohistochemistry,and statistical analysis was used to analyze the relationship between the expression of PBK and the clinicopathological features of prostate cancer in the microarray and Taylor database. Results The expression of PBK in prostate cancer was significantly higher（P = 0. 001）,and the expression increased in the group of high Gleason score（P = 0. 001）. The Taylor database obtained similar results,and Kaplan-Meier analysis showed that PBK was significantly correlated with the biochemical recurrence free survival（P =0. 007）. Finally,Cox regression model was used to analyze the prognostic factors of prostate cancer. Result shows that,the high expression of PBK（P = 0. 041）,Gleason score and pathological stage were independent predictors of biochemical recurrence of prostate cancer. Conclusion The expression of PBK is closely related to prostate cancer,and can be used as a molecular marker for clinical diagnosis and treatment.