乳腺癌组织中SIRT1的表达观察

SIRT1 expression in breast cancer

目的观察乳腺癌组织中沉默信息调节因子(SIRT1)的表达并探讨其临床意义。方法选取70例乳腺癌组织和20例乳腺纤维腺瘤组织,应用免疫组化法观察SIRI1在两组中的表达,并分析其与临床病理参数、预后之间的关系。结果 SIRT1在乳腺癌组织中和乳腺纤维腺瘤组织中的阳性表达分别为:62.9%(44/70)、35%(7/20),P<0.05;SIRT1的表达与乳腺癌的病理分期及淋巴结转移有关,P<0.05;SIRT1表达阳性和阴性患者2年无疾病进展生存率分别为40.6%和73.7%,P<0.05。结论乳腺癌组织中SIRT1的阳性表达率较高,并与乳腺癌的发生、发展、侵袭、转移、预后有关。

Objective To investigate the sirtuin（SIRT1） expression in breast cancer and its relationship with clinicopathological parameters in breast tissue. Methods We used immunohistochemical staining（Envision two-step） to detect the expression of 70 cases of breast cancer and 20 cases of breast fibroadenoma of SIRT1. Results The positive expression of sirt1 in breast cancer and breast fibroadenoma tissues were 62. 9 %（44/70） and 35 %（7/20）,P〈0. 05. The expression of sirt1 was correlated with the pathological stage and lymph node metastasis of breast cancer,P〈0. 05. The 2-year survival rates of sirt1 positive and negative patients were 40. 6 % and 73. 7 %,respectively,P〈0. 05. Conclusion The positive expression rate of sirt1 in breast cancer is higher,and is related to the occurrence,development,invasion,metastasis and prognosis of breast cancer.