网络药理学方法研究石菖蒲治疗神经退行性疾病的作用机制

Study the Mechanism of Acorus tatarinowii on Neurodegenerative Diseases by Network Pharmacology

目的从系统水平研究石菖蒲治疗神经退行性疾病的有效成分和作用机制。方法采用计算机网络药理学方法 ,从中药系统药理学数据库中筛选石菖蒲治疗神经退行性疾病的活性成分,并构建药物-靶标-疾病网络。结果通过网络药理学方法筛选出石菖蒲活性成分20种,显示该中药化学成分和作用靶点与阿尔茨海默病、抑郁症和帕金森综合征等神经退行性疾病之间存在一定的联系。结论通过网络药理学方法构建的石菖蒲网络可以将该中药化学成分的聚类、差异以及有效成分与相关靶标及疾病的复杂分子作用机制可视化。

Objective To explore the mechanism of the active components of Acorus tatarinowii on neurodegenerative diseases by using network pharmacology at the system level. Methods The active ingredients of Acorus tatarinowii on neurodegenera-tive diseases were screened from TCM systems pharmacology database by network pharmacology method, and the drugs-tar-gets-disease network was built. Results 20 active ingredients from Acorus tatarinowii were selected through the network phar-macology method. The results showed that those chemical compositions and related targets are correlated with the neurodegenerative diseases, such as Alzheimer＆#39;s disease, depression and Parkinson syndrome and so on. Conclusion The construction of Acorus tatarinowii network by the network pharmacology could visually trace out the cluster and diversity of compounds, and explore the complex molecular mechanism of Acorus tatarinowii in neurodegenerative diseases.