红细胞参数偏高对献血者及单采血小板质量影响的研究

Investigation on the effects of apheresis blood donors′ high red blood cell parameters on the quality of platelets

目的探究献血者红细胞参数偏高对单采血小板质量和献血者自身健康的影响。方法选择单采前红细胞计数(RBC)为5.5×10^(12)~6.5×10^(12) L^(-1)和血红蛋白(Hb)为160~175 g/L的献血志愿者78例为试验组;另选单采前RBC为3.5×10^(12)~5.5×10^(12) L^(-1)和Hb为120~160 g/L的献血志愿者92例为对照组。对比捐献单采血小板前后试验组和对照组血常规参数及单采血小板血常规恢复情况;观察试验组所捐献的单采血小板质量,对比两组单采血小板合格率的差异。结果单采前、单采后试验组的RBC、Hb均高于对照组,平均红细胞体积(MCV)均低于对照组,差异均有统计学意义(P<0.05),两组血小板计数(Plt)比较,差异无统计学意义(P>0.05),其余参数白细胞计数(WBC)、血细胞比容(Hct)、平均血红蛋白(MCH)等比较,差异无统计学意义(P>0.05);采集2周后,红细胞参数偏高献血者参数保持稳定;试验组献血者所捐献的WBC残留量和RBC混入量等均符合国家标准,与对照组比较,差异无统计学意义(P>0.05);试验组与对照组的单采血小板合格率比较,差异无统计学意义(P>0.05)。结论献血者红细胞参数偏高对单采血小板质量无影响,且血常规参数正常,不影响献血者自身健康。

Objective To investigate the effect of donor′s high parameter of red blood cell on the quality of platelet and their own health. Methods A total of 78 samples of experimental group were chose according to the indicators that red blood cell count（RBC） was 5.5×10^12~6.5×10^12L^（-1） and hemoglobin（Hb） was 160~175 g/L,while 92 samples of control group were selected according to the indicators that RBC was 3.5 ×10^12~5.5×10^12 L^-1 and Hb was 120 ~160 g/L. The research was conducted through comparing the routine blood parameters of both groups before and after platelets donation and comparing the restitution condition of both groups after two weeks of donation; moreover inspecting the quality of donated platelets from the experimental group and compared two groups′ conformity rate of platelets. Results Comparing the various inspected parameters of both groups′ samples collected before and after apheresis,in terms of RBC and Hb in experimental group were higher than those of the control group,while the mean corpuscular volume（MCV） were lower than the control group′s,thus the results of both comparations showed statistically significant（P〈0.05）;in term of the difference between two groups′ platelet count（Plt）,it showed no statistically significant（P〈0.05）;in terms of several remaining parameters,such as white blood cell count（WBC）,hematocrit（Hct）,mean corpuscular hemoglobin（MCH）,those differences showed statistically significant（P〈0.05）. The results noted above indicate that high red blood cell parameters had no effect on the platelet collection. Two weeks after blood collecting,each general parameters of those who have high red blood cell parament still remained stable,besides these parameters enable to rapidly return to the preoperative level. The quantity of the quantity of residual of WBC and mixing volume of RBC,which collected from the experimental group,were accordance with the national standards,therefore there were no statistically significant by comparing with control group′s（P〈0.05）. The difference between platelet conformity rates of the experimental group and the control group showed no sta-tistically significant（ P〈0. 05）. Conclusion High parameters of red blood cell has no effects on the quality of single donor platelets; moreover,the results of blood test are normal,thus high parameters of red blood cell do not affect the donor′s health.