射频消融治疗肝细胞癌的研究进展

Research advances in radiofrequency ablation in treatment of hepatocellular carcinoma

肝细胞癌是世界上癌症相关致死最常见的原因之一,仅20%的肝细胞癌患者可以行根治性治疗。许多临床研究证实射频消融可提供良好的局部控制,且安全性高,可作为根治性手术的替代。从射频消融治疗肝细胞癌的适应证、疗效及其与根治性手术切除和经肝动脉化疗栓塞术治疗效果的比较等方面进行了综述,认为需按照患者的个体化情况选择合适的治疗方案。

Hepatocellular carcinoma（HCC） is one of the most common causes of cancer-related death in the world,and only 20% of HCC patients can undergo radical treatment.Radiofrequency ablation induces coagulative necrosis of cells via thermal energy,kills tumor cells,and makes it possible to cure HCC.Many clinical studies have confirmed that radiofrequency ablation provides good local control and has high safety,and therefore,it can be used to replace radical surgery.This article reviews the indications and therapeutic effect of radiofrequency ablation in the treatment of HCC,as well as its comparison with radical surgical resection and transarterial chemoembolization in terms of their therapeutic effects.It is pointed out that the treatment regimen should be selected based on the patient＇s individualized conditions.