扩大切除及角膜缘干细胞移植联合丝裂霉素C治疗复发性翼状胬肉的美容疗效观察

Cosmetic Effect of Recurrent Pterygium Extended Excision Combined with Corneal Limbal Stem Cells Autograft Transplantion and Mitomycin C

目的:观察扩大切除及角膜缘干细胞移植联合丝裂霉素C治疗复发性翼状胬肉的美容效果。方法:收集复发性翼状胬肉患者78例86眼,在显微镜下行翼状胬肉扩大切除及角膜缘干细胞移植联合丝裂霉素C应用,术后随访观察3~24个月。结果:86眼复发性翼状胬肉患者中61例患者术眼舒适,角膜、结膜面光滑平整,表面无充血,无新生血管及翼状胬肉组织再复发;15眼出现结膜轻度充血及结膜瘢痕形成,再复发4眼。结论:扩大切除联合角膜缘干细胞移植联合撕裂霉素C治疗复发性翼状胬肉再复发率低,美容效果好。

Objective To observe the clinical effect of pterygium extend excision with corneal limbal stem cells autologous transplantion in treating pterygium. Methods Seven hundred and forty-eight cases of pterygium patients for the first time（seven hundred and seventy-two eyes） were treated from January 2005 to January 2014 in our hospital. They underwent pterygium excision combined with extensive resetion of the lesion area of the fascia and residual conjuntival resetion and autologous corneal limbal stem cells transplantion. Treatment effects of recurrence rate and wound recovery for comeal and bulbar conjunctive were observed. Results Patients were followed up for 6-24 months （means, 15 months） after operation,recurrence rate of pterygium is 3.6 percent,In no recurrence of pterygium, wound recovery for corneal and bulbar conjunctive were good and the appearance improved significantly. Conclusion It is effective and safe that pterygium extended excision with comeal limbal stem cells autograft transplantation. It has low recurrence causes less discomfort, take less time and helps wound surface to heal quickly.