摘要
目的探讨大环内酯类抗生素序贯疗法治疗小儿支原体肺炎的临床疗效及安全性。方法选择112例小儿支原体肺炎患儿,随机均分为两组。在常规对症治疗的基础上,观察组采取红霉素静滴联合阿奇霉素口服序贯治疗,对照组采取阿奇霉素静滴联合阿奇霉素口服序贯治疗。结果观察组的总有效率明显高于对照组(P<0.05)。观察组的发热消失时间、咳嗽消失时间、肺部啰音消失时间及疗程均明显短于对照组(P<0.05)。观察组的恶心呕吐、腹痛腹泻、注射部位疼痛发生率均明显低于对照组(P<0.05)。结论大环内酯类抗生素序贯治疗小儿支原体肺炎的疗效肯定,红霉素联合阿奇霉素序贯疗法有利于缩短治疗时间,改善患儿临床症状,减轻不良反应,提高治疗效果。
Objective To explore the curative effect and safety of macrolide antibiotics for sequential therapy in the treatment of children with mycoplasrna pneumonia. Methods 112 cases of children with mycoplasma pneumonia were selected and randomly divided into two groups, with 56 cases in each group. On the basis of routine symptomatic treatment, the control group received sequential therapy with intravenous drip of azithromycin and oral administration of azithromycin, while the observation group received sequential therapy with intravenous drip of erythromycin and oral administration of azithromycin. Results The total effective rate of observation group was significantly higher than that of control group (P 〈0.05). The fever disappeared time, cough disappeared time, pulmonary rale disappeared time and course of treatment of observation group were significantly shorter than those of control group (P〈0.05). The incidences of nausea / vomiting, abdominal pain / diarrhea, and injection site pain of observation group were significantly lower than those of control group (P〈0.05). Conclusions Macrolide antibiotics for sequential therapy has exact curative effect for children with mycoplasma pneumonia. Sequential therapy with erythromycin and azithromycin can help to shorten treatment time, improve children's clinical symptoms, reduce the adverse reactions, and improve curative effect.
作者
徐颖
李自强
许锦姬
XU Ying LI Ziqiang XU Jinji(Department of Pediatrics, Bao'an District Women and Children Health Care Hospital, Shenzhen 518133, China)
出处
《临床医学工程》
2017年第8期1127-1128,共2页
Clinical Medicine & Engineering
关键词
红霉素
阿奇霉素
序贯治疗
小儿
支原体肺炎
Erythromycin
Azithromycin
Sequential therapy
Children
Mycoplasma pneumonia