短暂性脑缺血发作患者血清LP(a)、ApoB/ApoA1水平与颈动脉粥样硬化的关系

Relationship Between Carotid Artery Atherosclerosis and Serum LP(a),ApoB/ApoA1 Levels in Patients with Transient Ischemic Attack

目的探讨短暂性脑缺血发作患者血清LP(a)、ApoB/ApoA1水平与颈动脉粥样硬化的关系。方法选择80例健康体检者(对照组)和80例短暂性脑缺血发作患者(观察组)为研究对象,两组均进行颈动脉超声检查和血清LP(a)、ApoB/ApoA1检测。结果观察组患者的血清LP(a)水平为(345.25±24.69)mg/L,ApoB/ApoA1为1.59±0.45,LDL为(3.58±0.74)mmol/L,Hs-CRP水平为(5.36±1.36)mg/L,均显著高于对照组,差异有统计学意义(P<0.05)。观察组患者中,有斑块患者的血清LP(a)水平、ApoB/ApoA1水平均显著高于无斑块患者,差异有统计学意义(P<0.05)。结论短暂性脑缺血发作患者的颈动脉粥样硬化发生与血清LP(a)、ApoB/ApoA1水平密切相关。

Objective To investigate the relationship between carotid atherosclerosis and serum LP （a）, ApoB/ApoA1 levels in patients with transient ischemic attack. Methods 80 healthy subjects （control group） and 80 cases of patients with transient ischemic attack （observation group） were selected as research objects. All cases received carotid artery ultrasound examination and detection of serum LP（a） and ApoB/ApoA1. Results The levels of serum LP（a）, ApoB/ApoA1, LDL and Hs-CRP of observation group were （345.25 ± 24.69） mg/L, 1.59 ± 0.45, （3.58±0.74） mmol/L and （5.36 ± 1.36） mg/L respectively, significantly higher than those of control group （P〈0.05）. In the observation group, patients with plaque had significantly higher levels of serum LP（a） and ApoB/ApoA1 than patients without plaque （P〈0.05）. Conclusions Carotid atherosclerosis in patients with transient ischemic attack is closely related to serum levels of LP（a） and ApoB/ApoAl.