复发或转移性食管癌患者放化疗后再应用紫杉类药物化疗引起肺炎的风险分析研究

Risk Analysis of Pneumonitis in Taxane Therapy after Chemoradiotherapy for Patients with Metastatic or Recurrent Esophageal Cancer

为了研究接受放化疗后的患者在应用紫杉类药物后肺炎的发生率是否会增加。笔者回顾性研究2004年9月到2015年6月接受紫杉类药物治疗的129例转移性或复发性食管癌患者,对比研究包括肿瘤部位、临床分期、有无肺转移、既往有无放射性肺炎及放疗与紫杉醇药物应用的间隔时间等多项指标。结果显示发生肺炎的独立危险因素为末次放疗距紫杉类药物治疗间隔≤4个月。因此说明末次放疗距紫杉类药物治疗时间间隔太短是发生肺炎的重要因素,应适度拉长放疗同紫杉醇药物应用的时间间隔。

This study aimed to clarify the risk of pneumonitis in patients with esophageal cancer who receive taxane therapy after chemoradiotherapy.The data of 129 patients with metastatic or recurrent esophageal cancer who initiated taxane therapy between September 2004 and June 2015 were retrospectively analyzed.Many indicators were comparatively studied such as the tumor site,clinical stage,pulmonary metastasis,radioactive pneumonia and the time between Radiation therapy exposure and taxane initiation.The results showed a short period between the last Radiation therapy exposure and taxane initiation is an independent risk factor for pneumonitis development.So we should be modestly elongate the time between the last RT exposure and taxane initiation.