急性脊髓损伤的药物治疗

Pharmacological Therapy of Spinal Cord Injury

急性脊髓损伤是一种常见的高能量损伤,目前对于其病理生理机制已有较为深入的认识,在诊断与手术治疗方面也已初步形成共识,但在早期药物治疗方面可选方案有限,部分药物治疗方案在临床应用中因缺乏设计严密的临床研究,其疗效亦存在争议。本文系统回顾了甲基泼尼松龙和神经节苷脂等近年来常用急性脊髓损伤治疗药物应用理念的发展,根据急性脊髓损伤机制总结了数种较有应用前景的新药,以期指导并规范现有药物治疗决策,并为治疗急性脊髓损伤提供新的临床思路。

Acute spinal cord injury is a kind of high-energy injury,although intensive comprehension of its physiopathologic mechanism and consensus on diagnosis as well as surgical treatment have achieved,available projects of pharmacotherapy at early stage are still limited,and some treatments are still controversial during clinical application for lack of welldesigned clinical trials.The literature systematically reviewed the application concepts development of frequently-used medicine for acute spinal cord injury such as methylprednisolone and ganglioside in recent years and summarized some kinds of promising new medicine according to the mechanism of acute spinal cord injury.The authors hope to guide and normalize clinical decision,meanwhile providing new method for the treatment of acute spinal cord injury.