Notch信号通路在婴儿血管瘤发病机制中的作用

Role of Notch signaling pathway in the pathogenesis of infantile hemangioma

婴儿血管瘤是婴幼儿最常见的良性肿瘤，目前有关婴儿血管瘤增殖和消退的机制尚未明确，仅局限于婴儿血管瘤形成的分子机制研究。多认为婴儿血管瘤的发生与血管内皮细胞异常增殖及碱性成纤维细胞生长因子、血管内皮细胞生长因子等细胞因子的异常表达有关。近年研究提示，Notch信号通路在婴儿血管瘤发生发展中发挥重要作用。Notch信号刺激血管内皮生长因子，通过调节血管内皮生长因子及其受体，调控血管内皮细胞增殖，参与婴儿血管瘤增生和退化。明确Notch信号在婴儿血管瘤发生机制中的作用，将为婴儿血管瘤提供合理的治疗方向。

Infantile hemangioma is the most common benign neoplasm in infants. At present, studies are mostly limited to the molecular mechanism of the formation of infantile hemangioma, but the mechanism of its proliferation and regression is still unclear. It is considered that the occurrence of infantile hemangioma is related to abnormal proliferation of vascular endothelial cells and aberrant expression of cytokines, such as basic fibroblast growth factor （bFGF） and vascular endothelial growth factor （VEGF）. Recent studies have suggested that Notch signaling pathway plays an important role in the occurrence and development of infantile hemangioma. Notch signals participate in the proliferation and degeneration of infantile hemangioma by stimulating and regulating VEGF and its receptors as well as affecting the proliferation of vascular endothelial cells. Clarifying the role of Notch signaling pathway in the pathogenesis of infantile hemangioma will provide rational treatments of infantile hemangioma.