EB病毒及其相关皮肤淋巴瘤

Epstein-Barr virus and associated cutaneous lymphomas

EB病毒在人群中感染率极高，现已发现与多种人类疾病相关，其中包括具有明显异质性的多种皮肤淋巴瘤，如结外自然杀伤细胞/T细胞淋巴瘤、种痘样水疱病皮肤T细胞淋巴瘤、霍奇金淋巴瘤、Burkitt淋巴瘤、HIV相关的淋巴瘤等。EB病毒相关皮肤淋巴瘤临床表现多样，组织学呈谱系改变，慢性病程或经过凶险，大部分预后不良。EB病毒致肿瘤机制尚不明确，可通过其功能性分子与宿主的相互作用，逃逸宿主细胞免疫、调节多种信号通路、促肿瘤炎症、诱导血管形成、致基因突变，从而永生化宿主细胞。临床上应跟踪监测高危人群，如营养不良人群和免疫受损人群，特别是儿童、老年人、器官移植患者，HIV等患者EB病毒变化，对EB病毒相关皮肤淋巴瘤进行早期诊断与干预。

Epstein-Barr virus （EBV） infection rate is very high in populations. It has been found that EBV is associated with many human diseases including an obviously heterogeneous group of cutaneous lymphomas, such as extranodal natural killer （NK）/T-cell lymphoma, hydroa vacciniforme-like lymphoma, Hodgkin＇s lymphoma, Burkitt＇s lymphoma, HIV-associated lymphoma and so on. EBV-associated cutaneous lymphomas have various clinical manifestations, a spectrum of histological changes with chronic or critical disease course and poor prognosis. Mechanisms of EBV- mediated oneogenesis are still unclear. By the interaction between functional molecules of EBV and the host, EBV can escape from cellular immunity in host, modulate multiple signaling pathways, promote tumor inflammation, induce blood vessel formation and gene mutations, and finally immortalize host cells. In clinic, high-risk population should be tracked and monitored, such as undernourished and immunoeompromised persons, especially children, the elderly, organ transplant patients, and HIV-infected individuals, so as to early diagnose and interfere in EBV- associated cutaneous lymphomas.