寻常型银屑病患者皮损中瘦素、脂联素与血管内皮生长因子表达的研究

Study on the expression of leptin,adiponectin and vascular endothelial growth factor in the skin lesions of patients with psoriasis vulgaris

目的 探讨寻常型银屑病患者皮损中瘦素、脂联素及其血管内皮生长因子vascular endothelial growth factor（VEGF）的变化与意义.方法 ①采用免疫组织化学技术检测34例寻常型银屑病患者和21例正常人皮损中瘦素、脂联素与VEGF表达水平.结果 同正常对照组相比,寻常型银屑病患者皮损中瘦素、脂联素以及血管内皮生长因子表达明显高于正常对照组,强阳性率分别为17.65%、17.65%和14.7%,差异有统计学意义（χ^2=9.18,P〈0.05;χ^2=13.34,P〈0.05;χ^2=18.9,P〈0.05）,相关分析表明,瘦素表达水平与VEGF表达水平呈正相关（r=0.8,P〈0.05）,脂联素与VEGF无相关（r=-0.02,P〉0.05）.结论 寻常型银屑病患者皮损中瘦素、脂联素及其VEGF水平的变化可能与银屑病的发病有关,而血管内皮生长因子的变化可能与瘦素有关.

Objective To investigate the changes and significance of leptin,adiponectin and vascular endothelial growth factor（VEGF） in patients with psoriasis vulgaris.Methods The expression levels of leptin,adiponectin and vascular endothelial growth factor in 34 patients with psoriasis vulgaris and 21 normal controls were detected by immunohistochemical technique.Results Compared with the normal control group,in the skin lesions of patients with psoriasis vulgaris leptin,the expression of adiponectin and VEGF expression was significantly higher,the strongly positive expression proportion was 17.65% and 17.65%,14.7% respectively.The difference is statistically significant （χ^2=9.18,P〈0.05;χ^2=13.34,P〈0.05;χ^2=18.9,P〈0.05）,correlation analysis showed that the expression of leptin and VEGF levels was positively correlated （r=0.8,P〈0.05）.Adiponectin and VEGF had no correlation.Conclusion In the skin lesions of patients with psoriasis vulgaris leptin,adiponectin and VEGF levels may be related to the pathogenesis of psoriasis,and the level of VEGF might be related with leptin.