肿瘤代谢异质性的研究进展

Heterogenesis in Cancer Metabolism

肿瘤的发生、发展过程伴随着明显的代谢变化。肿瘤是一个异质性的、多细胞相互作用的整体,这决定了肿瘤的代谢模式是具有高度异质性并与微环境相互作用的,而非单一且孤立的。近来的研究表明,肿瘤及微环境中细胞的代谢改变为肿瘤的生长及恶性进展创造了有利条件。肿瘤多样的能量来源、灵活的代谢调控,保证了肿瘤细胞在增殖、转移过程中不受血运等因素的限制。肿瘤内不同群体间通过代谢偶联相互调控,促进炎症环境形成,抑制免疫系统活性,为肿瘤创造了一个有利的生长环境。该综述将讨论肿瘤灵活异质的、多细胞互作的代谢模式对提高肿瘤的生存能力及其对临床疗效的影响。

The origination and malignant process of tumor is accompanied with metabolic disorder. The tumor is heterogeneous with multi-cellular interaction, which determines that the metabolic pattern of the tumor is highly heterogeneous and interacts with dynamic microenvironment rather than homogeneous and independent. Recent studies have shown that metabolic reprogramming of tumor cells or the cells located in the microenviroment creates favorable conditions for tumor growth and malignant progression. Multiple fuel choices of tumor guarantee tumor growth and metastasis without limitation of blood supply. Metabolic coupling within different components of tumor contributes to inflammation maintaining and anti-tumor immunity inhibition, therefore creates a favorable environment. This review will discuss how the flexible, heterogeneous and multi-interaction characters of tumor metabolism benefits the viability and influences clinical therapeutic effect.