HIV相关痴呆脑萎缩MRI动态观察

Dynamic Observation of HIV Associated Dementia Brain Atrophy in MRI

目的对H I V相关痴呆(H I V associated dementia,HAD)脑萎缩患者进行动态追踪观察,探索脑萎缩的演变与HIV相关痴呆进展的相关性。方法对进行1至9个月动态观察的16例HIV相关痴呆的脑萎缩MRI资料进行回顾性分析,统计分析HIV相关痴呆的痴呆进展与脑萎缩的相关性。结果 16例HIV相关痴呆病例随着脑萎缩的进展,出现国际人类免疫缺陷病毒相关性痴呆量表(International HIVAssociated Dementia Scale,IHDS)评分的降低。MRI主要表现为进行性的脑萎缩和脑白质病变,表现为额叶皮层的进行性变薄,基底节灰质核团体积变小,脑沟及脑室系统进行性扩张,皮层下及半卵圆中心脑白质斑片影范围进行性扩大。全部病例脑萎缩的进展与IHDS评分为负相关(P<0.05)。结论脑萎缩的进展与IHDS评分为负相关,本研究对临床诊断HAD和判断预后有积极意义。

Objective To explore the correlation between the development of brain atrophy and the progression of HAD by dynamic tracing of 16 patients with HAD. methods The MRI data of 16 patients with HAD were analyzed retrospectively, and the correlation between dementia progression of HAD and brain atrophy was analyzed retrospectively from 1 to 9 months.Results A total of 16 cases of HAD with the development of brain atrophy, accompanied by the IHDS score decreased. The main manifestations of MRI were progressive brain atrophy and white matter lesions. The results showed that the frontal cortex became thinner, the volume of basal ganglia becalne smaller, and the expansion of the cerebral sulci and ventricles system. The results of statistical analysis showed that there was a negative correlation between brain atrophy and IHI）S score （P〈0.05）. Conclusion The development of brain atrophy was negatively correlated with IHDS score. This study has positive significance for clinical diagnosis of HAl） and prognosis.