摘要
目的检测肺癌及肺良性病变患者血清血清癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)、非小细胞肺癌相关抗原21-1(CYFRA21-1)、糖类抗原125(CA125)及铁蛋白(Fer)的水平,探讨其在肺癌诊断中的应用价值。方法采用电化学发光法检测103例肺癌和32例肺良性病变患者及40例健康人群血清中的CEA、NSE、CYFRA21-1、CA125及Fer水平,并进行比较。结果肺癌组CEA、NSE、CYFRA21-1、CA125及Fer的水平分别为(110.2±95.5)ng/mL、(50.6±43.4)ng/mL、(32.8±29.5)ng/L、(122.7±110.4)U/L、(854.6±497.2)ng/mL,明显高于对照组和肺良性病变组(t=6.21、5.71、6.75、6.62、7.74,P<0.05;t=5.26、4.86、5.81、5.20、6.26,P<0.05);CEA、NSE、CYFRA21-1、CA125及Fer诊断肺癌的灵敏度分别为39.81%、24.27%、71.84%、68.93%、77.66%,5项指标联合检测灵敏度为96.12%、特异度为95.00%。结论 5项肿瘤标记物联合检测能明显提高肺癌的检出率,有利于肺癌的早期诊断,可以广泛应用于临床中。
Objective To evaluate the clinical value of serum carcinoembryonic antigen(CEA),neuron specific enolization enzyme(NSE),21-1non-small cell lung cancer associated antigen(CYFRA21-1),carbohydrate antigen 125(CA125)and ferritin(Fer)in the diagnosis of lung cancer.Methods The levels of CEA,NSE,CYFRA21-1,CA125 and Fer were measured by electrochemlium-inescence in 103 patients with lung cancer,32 patients with benign lung diseases and 40 healthy people.Results The serum levels of CEA,NSE,CYFRA21-1,CA125 and Fer in patients with lung cancer[(110.2±95.5)ng/mL,(50.6±43.4)ng/mL,(32.8±29.5)ng/L,(122.7±110.4)U/L,(854.6±497.2)ng/mL]were significantly higher than those in patients with benign lung diseases and those in healthy people(t=6.21,5.71,6.75,6.62,7.74,P〈0.05;t=5.26,4.86,5.81,5.20,6.26,P〈0.05).The sensitivity values of CEA,NSE,CYFRA21-1,CA125,Fer and the combined determination containing five tumor markers were 39.81%,24.27%,71.84%,68.93%,77.66% respectively.The sensitivity and specificity of the combined determination containing five tumormarkers were 96.12%,95.00%.Conclusion The joint detection in the diagnosis of lung cancer could improve the sensitivity significantly,to help for early diagnosis of lung cancer,which is value to widely applied in clinic.
出处
《国际检验医学杂志》
CAS
2017年第14期1885-1886,1889,共3页
International Journal of Laboratory Medicine
基金
国家自然科学基金青年基金项目(H1613)
关键词
肺癌
癌胚抗原
神经元特异性烯醇化酶
非小细胞肺癌相关抗原21-1
糖类抗原125
lung cancer
carcinoembryonic antigen
neuron specific enolization enzyme
21-1 non-small cell lung cancer associated antigen
carbohydrate antigen 125