H型高血压患者血清过氧化物酶与踝臂指数的相关性研究

Relationship between myeloperoxidase and ankle brachial index in patients with htypehypertension

目的探讨H型高血压患者血清过氧化物酶(MPO)与踝臂指数(ABI)的相关性。方法选择133例高血压患者,根据血浆高同型半胱氨酸(Hcy)和诊室血压水平分为H型高血压组72例、非H型高血压组30例和正常血压组31例。测定Hcy、ABI、MPO水平。结果与正常血压组比较,H型高血压组和非H型高血压组ABI明显降低(P<0.05);与非H型高血压组比较,H型高血压组ABI明显降低(P<0.05)。与正常血压组比较,H型高血压组MPO、CRP明显升高(P<0.05)。H型高血压组患者ABI与CRP和MPO呈负相关(r=-0.712、-0.722,P<0.05)。结论 ABI与MPO、Hcy密切相关,对评估H型高血压患者动脉功能损伤及识别高危患者有重要的临床意义。

Objective To investigate the relationship between myeloperoxidase（MPO）and ankle brachial index（ABI）in patients with htypehypertension.Methods A total of 133 patients were enrolled in this study,and divided in to htypehypertention group（n=72）,non-htypehypertension group（n=30）and normotension group（n=31）.Their Hcy,ABI and MPO levels were measured and compared.Results The ABI in htypehypertention group and non-htypehypertension was significantly lower than that in normotension group（P〈0.05）,ABI in non-htypehypertension group was lower than that of htypehypertonsion group（P〈0.05）.MPO and CRP in the htypehypertension group was significant higher that those of normotension group（P〈0.05）.The ABI was negatively related with the serum MPO and CRP levels in htypehypertention group（r=-0.712,-0.722,P〈0.05）.Conclusion ABI is closely related with MPO,and play an important role in diagnosis of artery function impairment and high risk of htypehypertension patients.