类风湿关节炎患者血清中C反应蛋白、脂联素水平与患者病情严重程度及患者关节功能的关系

Relationship between serum levels of C reactive protein,adiponectin and severity of disease,joint function in patients with rheumatoid arthritis

目的探讨类风湿关节炎(RA)患者血清中C反应蛋白(CRP)、脂联素(APN)水平与患者病情严重程度及患者关节功能的关系。方法选择2014年9月至2016年8月该院治疗的85例RA患者纳入RA组,同期20例健康体检者为对照组,检测患者血清中CRP、APN,探讨CRP、APN水平与患者RA患者病情及患者关节功能的关系。结果 RA患者CRP为(23.63±5.36)pg/mL明显高于对照组;APN、APN/CRP分别为(4.64±1.74)ng/mL、0.37±0.06,明显低于对照组,差异均有统计学意义(P<0.05)。RA患者关节损伤越严重,APN、APN/CRP越低,而CRP水平越高,且组间差异均有统计学意义(P<0.05)。病情活动分级越高的患者APN、APN/CRP越低,而CRP水平越高,且差异有统计学意义(P<0.05)。Logistic分析结果提示APN(P=0.04)、APN/CRP(P=0.01)是RA患者出现骨损伤的独立危险因素。结论血清中CRP、APN水平与RA患者病情严重程度及患者关节功能密切相关。

Objective To study the relationship between serum levels of C reactive protein,adiponectin and severity of disease,joint function in patients with rheumatoid arthritis（RA）.Methods A total of 85 cases of RA treated in our hospital from September 2014 to August 2016 were selected into the RA group,and 20 healthy persons were recruited into control group.The serum C reactive protein,adiponectin were detected,compared in the two groups,and to investigate the relationship between them with severity of disease,joint function of the patients.Results C reactive protein of RA patients was（23.63±5.36）pg/mL,which was significant higher than that of the control group,the adiponectin,the ratio of C reactive protein and adiponectin were（4.64±1.74）ng/mL,0.37±0.06 respectively,which were significant lower than those of the control group,the differences were statistically significant（P〈0.05）.RA patients with more serious joint injury and disease status,the adiponectin,the ratio of adiponectin and C reactive protien were more lower,the C reactive protien was more higher,the differences in different joint injury and disease status groups were significant（P〈0.05）.Logistic analysis showed that adiponectin（P=0.04）,the ratio of adiponectin and C reactive protien（P=0.01）were independent risk factors of bone damage in RA patients.Conclusion Serum C reactive protein and adiponectin level were closely related to the severity of RA and joint function.