电子垃圾拆解区人群甲状腺激素水平改变的Meta分析

Meta-analysis on thyroid hormone levels of populations from e-waste dismantling regions

目的:评价暴露于电子垃圾拆解区对人体血清甲状腺激素水平的影响。方法:检索PubMed、Web of Science、Elsevier电子期刊、中国知网、万方数据库等中英文数据库,收集国内外发表的评价人体血清甲状腺激素水平与电子垃圾拆解区暴露相关性的随机对照研究,检索时间从建库至2017年4月。应用RevMan 5.2软件进行Meta分析。结果:共纳入9篇相关研究,样本量包括暴露组489例、对照组489例。结果显示,电子垃圾拆解区人群血清总甲状腺素(T4)、游离甲状腺素(FT4)水平较对照组低(P<0.05)但游离三碘甲状腺原氨酸(FT3)、血清总三碘甲状腺原氨酸(T3)和促甲状腺激素(TSH)与对照组的差异无统计学意义(P>0.05)。结论:暴露于电子垃圾拆解区可能会引起人甲状腺功能的改变。

OBJECTIVE：To evaluate correlations between serum thyroid hormone levels and exposure to toxic substances from e-waste dismantling regions.METHODS：Randomized-control studies on correlations between serum thyroid hormone levels and exposure to toxic substances from e-waste dismantling areas that were reported on PubMed, Web of Science,Elsevier,CNKI and WanFang Database up to April 2017 were searched and analyzed. The data of the included studies were analyzed using Revman 5.2.RESULTS：9 randomized-controlled studies were identified including 489 people exposed to toxic chemicals from e-waste dismantling areas and 489 people of control. Serum 1evels of total thyroxine （T4） and free thyroxine （FT4） in the expose groups were significantly lower than those in the control groups （P〈0.05）,while there were no significant differences in the serum levels of free triiodothyronine （FT3）,total triiodothyronine （T3） and thyrotropin （TSH）（P〉0.05）.CONCLUSION：Exposed to toxic chemicals from e-waste dismantling regions may affect the serum level of thyroid hormone.