Ets-1在子宫内膜癌中的表达及意义

The expression and clinical significance of Ets-1 in endometrial carcinoma

目的:探讨Ets-1在子宫内膜癌组织中的表达及其与临床分期、病理分级、分型及预后的关系。方法:免疫组化SP法检测子宫内膜癌及正常子宫内膜组织中Ets-1表达,荧光原位杂交法检测Ets-1 mRNA表达。结果:子宫内膜癌组织中Ets-1蛋白阳性表达率为88.8%,高于正常子宫内膜。子宫内膜癌组织中Ets-1表达与临床病理分期、肌层浸润与病理分级有关,差异有统计学意义(P<0.05)。结论:Ets-1与子宫内膜癌的临床分期、病理分级、转移密切相关。

Objective： To investigate the expression of Ets-1 in endometrial carcinoma tissues,the relationship between Ets-1 and clinical stage,pathological grading and typing of endometrial carcinoma.Methods： The expression of Ets-1 was detected in endometrial carcinoma and normal endometrium using imunohistochemical sp method and fluorescence in situ hybridization. Results： The positive expression of Ets-1 protein in endometrial carcinoma rate was88.8%,was higher than normal endometrial tissue.The expression of Ets-1 in endometrial carcinoma was correlated with clinicopathological stage,muscular layer infiltration and pathological grading（ P0. 05）. Conclusion： Ets-1 is closely related to clinical stage,pathological grading and metastasis of endometrial carcinoma.