血清IL-9及TGF-β在结直肠癌患者中的表达及临床意义

Expressions of serum IL-9 and TGF-β and their clinical significance in patients with colorectal cancer before and after surgery

目的探讨白介素-9(IL-9)及转化生长因子(TGF-β)在结直肠癌患者的表达及临床意义。方法以2015年1月至2015年12月于本院接受结直肠癌手术的186例患者为例,检测手术前、手术结束后10 d的IL-9及TGF-β水平,分析术前IL-9及TGF-β水平与临床病理特征的关系。术后随访1年,分别检测术后复发与未复发者IL-9及TGF-β水平。选择同期于本院体检的健康人群为对照组,上述指标均以对照组检测结果为基准参考进行比较。结果术前血清IL-9及TGF-β表达水平与肿瘤直径及病理分期有关(P<0.05)。术前血清IL-9及TGF-β水平均显著高于术后及对照组(均P<0.05)。随访1年,期间复发患者的IL-9及TGF-β水平显著高于对照组(均P<0.05),未复发患者上述指标水平与对照组差异均无统计学意义(均P>0.05)。结论结直肠癌患者术前及术后1年复发患者的血清IL-9及TGF-β水平呈显著升高,术后定期复查上述指标可对评估患者预后有一定的参考价值。

Objective To investigate the clinical significance of interleukin-9（IL-9） and transforming growth factor β（TGF-β） in patients with colorectal cancer. Methods Fresh serum were obtained from 186 patients（before surgery, 10 days after surgery,patients with or without relapse after 1 year） and 60 healthy donors. The expression levels of IL-9 and TGF-β1 in the blood specimens were determined using ELISA. Results The serum levels of IL-9 and TGF-β increased with the tumor size and clinical stage of tumor.The serum levels of IL-9 and TGF-β in patients before surgery were higher than those in patients after surgery and healthy donors.The levels of IL-9 and TGF-β in patients with relapse increased after one year. Conclusion Monitoring serum IL-9 and TGF-β can improve the evaluation of the immune status of patients with colorectal cancer after surgery. It can provide valuable insight for early immune intervention to prevent relapse and for new drug development.