乌司他丁在重度有机磷中毒治疗中的疗效分析

Analysis of the Efficacy of Ulinastatin in the Treatment of Severe Organophosphorus Poisoning

目的探讨乌司他丁在重度有机磷中毒治疗中的疗效。方法将98例重度有机磷中毒患者随机分为两组,常规组给予传统常规治疗,实验组在常规治疗的基础上加用乌司他丁;动态观察胆碱酯酶(CHE)的变化,记录CHE恢复80%的时间,对照两组脏器功能损害发生率,并动态比较两组间肿瘤坏死因子(TNF-a)。结果实验组CHE恢复时间及CHE恢复80%的时间均显著优于对照组,差异均有统计学意义(P<0.05),实验组血TNF-a较常规组明显下降且脏器功能损害发生率明显降低(P<0.05)。结论乌司他丁对治疗重度有机磷中毒效果明显,其可能与抑制全身炎症反应,保护多脏器功能有关。

Objective To investigate the efficacy of ulinastatin in the treatment of severe organophosphate poisoning. Methods 98 patients with severe organophosphorus poisoning were randomly divided into two groups.The conventional group was treated with conventional therapy. The exper-imental group was treated with ulinastatin on the basis of routine therapy. The changes of cholinesterase CHE recovered 80% of the time,control the incidence of two groups of organ damage,and dynamic comparison between the two groups of TNF-a. Results The recovery time of CHE and the time of CHE recovery were significantly better than those of the control group（ P 〈 0.05）. The level of TNF-a in the experimental group was significantly lower than that in the control group Significantly decreased（ P 〈 0. 05）. Conclusion Ulinastatin is effective in the treatment of severe organopho-sphate poisoning,which may be related to the inhibition of systemic inflammatory response and the protection of multiple organ function.