摘要
核酸适配体和靶物质具有良好的亲和力、高特异性等特性,在药物靶向递送系统研究领域具有很大的应用价值。到目前为止,不同种类的基于核酸适配体药物系统已被报道。本综述总结了核酸适配体介导无机纳米材料在靶向抗肿瘤的最新研究进展,并对其存在的问题和未来的研究方向进行了展望。
Aptamers have good affinities and high specificity with target molecules, and other characteristics, thus own great potentialities in the drug delivery systems. So far, different types of aptamer based drug systems have been reported. This review summarizes the recent advances of aptamers mediated inorganic nanomaterials in targeted cancer therapy, as well as their existing problems and thture research directions.
作者
贺芬
刘艳飞
刘珍宝
He Fen Liu Yanfei Liu Zhenbao(School of Chemistry and Chemical Engineering, Central South University, Changsha 410083 Xiangzva School of Pharmaceutical Sciences, Central South University, Changsha 410013)
出处
《生命科学仪器》
2017年第3期19-22,共4页
Life Science Instruments
基金
高等学校博士学科点专项科研基金-新教师类(20130162120078)
国家自然科学基金青年基金(81301258)
湖南省自然科学基金(2016JJ2161)
中南大学升华育英计划研究基金
关键词
核酸适配体
无机纳米材料
递药系统
肿瘤靶向治疗
Aptamer
Inorganic nanomaterials
Drug delivery system
Cancer targeted therapy
