HIF-1在鼻息肉和鼻咽癌发生机制中的研究进展

Research Progress of HIF-1 in the Pathogenesis of Nasal Polyps and Nasopharyngeal Carcinoma

鼻息肉是鼻腔炎性黏膜上带蒂或广基的高度水肿的炎性组织,成人鼻息肉发生率为1%~4%,术后易复发。鼻咽癌是鼻咽部恶性肿瘤,病变部位隐匿、早期症状不典型、预后差,5年生存率大约50%。相关研究揭示了局部缺氧环境在鼻息肉和鼻咽癌发病、进展中有重要意义,其中HIF-1作为独特低氧环境细胞因子可参与调控细胞代谢、促进细胞增殖、加重炎症反应在鼻息肉和鼻咽癌的发生过程中可能扮有重要角色。

Nasal polyps are highly inflammatory tissues with pediele or wide base in the nasal mucosa, the incidence of adult nasal polyps was 1%-4%, which was easy to recur.Nasopharyngeal carcinoma is a malignant tumor of the nasopharynx, the location of the lesion and early symptoms are not typical, the prognosis is poor, 5 years survival rate was about 50%.Related studies have shown that the local hypoxic environment is of great significance in the development of nasal polyps and nasopharyngeal carcinoma, HIF-1 as the unique hypoxia cytokine involved in the regulation of cell metabolism, promote cell proliferation and increase the inflammatory response may play an important role in the process of nasa] polyps and nasopharyngeal carcinoma.