无载体^(188)Re标记氟哌酸的研究

A study on carrier-free ^(188)Re labelled norfloxacin

用188W/188Re发生器得到的188Re研制了具有潜在临床应用价值的188Re标记的氟哌酸(188Re-Norfloxacin)。研究了在无载体的条件下,pH值、温度、时间、氯化亚锡含量对标记率的影响,确定了最佳标记条件。实验结果表明:用无载体188Re标记的188Re-Norfloxacin的标记率为92%以上,标记后调pH为4,24h后,放化纯度基本不变。

Synthesis of the carrier free 188Re-norfloxacin was investigated using 188Re eluted from a 188W/188Re gen-erator. Stannous chloride was used as the reducing agent for the reduction of the carrier free 188Re. Influences of concentration of reducing agent, pH, temperature and reaction time on the labelling yield of 188Re-norfloxacin were examined and the optimum conditions were obtained. Under the optimum conditions, the labelling yield of 188Re-norfloxacin was more than 92%. The stability of 188Re-norfloxacin at pH 4 was studied. Radiochemical purity of 188Re-norfloxacin was nearly constant in 24 hours.