自体LAK-细胞回输治疗慢性乙型肝炎的近期HBeAg阴转效果

Use of Lymphokines Activated Killer Cells Re-infusion for the Treatment of Chronic Hepatitis B

本文介绍我科自1991年1月至6月采用自体LAK-细胞回输治疗慢性乙型肝炎21例。疗程结束,9例HBeAg阴转占42.9％。对照组20例中3例HBeAg阴转占15.0％,统计学处理P<0.01。结合临床观察、复习文献对自体LAK-细胞回输治疗乙肝机理进行了初步探讨。认为本治疗致HBeAg阴转效果明显,是目前抗病毒治疗比较理想的方法。

This paper gives an account of our experience in the treatment of 21 cases of chronic hepatitis B with reinfusing autologous lymphokines activated killer cells (LAK-cells) in our department from Jan. to June 1991. When the course of treatment terminated, HBeAg in 9 cases turned negative (42.9％), whereas in the control group of 20 cases, HBeAg in only 3 cases turned negative (P&lt;0.01). A preliminary exploration into the mechanism of treatment for reinfusing LAK-cells was attempted by clinical observation and literature review. Results show that this treatment proves effective and is up to date a satisfactory treament method for hepatitis B viruses.