脓毒症发病机制最新认识

Updated insights into the pathogenesis of sepsis

脓毒症及脓毒性休克是ICU常见的危重症,其病死率高且严重影响患者的生活质量。脓毒症发病机制复杂,涉及机体多个器官功能改变,对其发病本质的探索一直是全球的研究热点。文中将总结分析近年来脓毒症发病机制的研究进展,分别从炎症反应失衡、免疫功能紊乱、凝血异常以及神经-内分泌-免疫网络、线粒体损伤、内质网应激、细胞自噬、基因多态性等方面分析脓毒症的病理生理过程,为其临床防治提供理论依据。

Sepsis and septic shock are common critical diseases in the ICU,which have a high mortality and seriously affect the patients＇ quality of life. The pathogenesis of sepsis is very complicated and involves the changes in the functions of multiple systems and organs. Recently,the investigation into the potential mechanisms underlying the development of sepsis is becoming a hotspot all over the world. The author presents an overview on the advances in the studies of the pathogenesis of sepsis,relating to the imbalance of inflammatory response,immune dysfunction,abnormal blood coagulation,nerve-endocrine-immunity network,mitochondrial function damage,endoplasmic reticulum stress,autophagy,and genetic polymorphism,in order to provide some theoretical evidence for the prevention and treatment of sepsis in clinical practice.