氨氯地平联合缬沙坦治疗高血压合并糖尿病的效果及其对肾功能的影响

Efficacy of Amlodipine combined with Valsartan on Treatment of Hypertension with Diabetes and its Effect on Renal Function

目的探究氨氯地平联合缬沙坦治疗高血压合并糖尿病的效果及其对肾功能的影响。方法选择2015年4月~2016年11月我院收治的141例原发高血压合并糖尿病患者,根据治疗方式不同分为三组,每组47例。A组予以氨氯地平治疗,B组予以缬沙坦治疗,C组予以氨氯地平联合缬沙坦治疗。治疗后,比较三组肾功能水平、血压以及血糖水平。结果与C组相比,A组和B组舒张压和收缩压水平均明显提高,差异有统计学意义(P<0.05);C组空腹胰岛素和空腹血糖水平与A组和B组相比下降显著,差异有统计学意义(P<0.05);A组和B组的微量尿白蛋白排泄率(UAER)和24h尿蛋白定量水平均高于C组,差异有统计学意义(P<0.05)。结论对原发高血压合并糖尿病患者应用氨氯地平联合缬沙坦治疗,能起到降压与降糖效果,可较好的保护患者的肾功能。

Objective To investigate the clinical efficacy of amlodipine combined with valsartan on treatment of hypertension with diabetes and its effect on renal function.Methods： Totally, 141 patients with essential hypertension and diabetes were admitted and treated in our hospital from April 2015 to November 2016. They were randomly divided into three groups with 47 patients in each group, A group （treatment with amlodipine）, B group （treatment with valsartan）, and C group （treatment with amlodipine and valsartan）. After treatment, the renal function, blood pressure, and blood glucose were compared. Results： Comparing with A group and B group, the diastolic pressure, systolic pressure, festing insulin and fksting blood_glucose,urinary albumin excretion rate （UAER）, 24h urine protein excretion were significantly decreased in C group （P 〈 0.05）. Condusions： Application of amlodipine combined with valsartan on patients with essential hypertension and diabetes can achieve good results in anti-hypertension and anti- blood-glucose, protect renal function.