变异链球菌葡萄糖基转移酶转录调控因子的研究进展

Research Progress of Regulator of Streptococcus Mutans Glucosyltransferase

葡萄糖基转移酶是变异链球菌自身合成的一种重要的固有酶,是变异链球菌重要的致龋因子,它以蔗糖作为代谢底物,合成生物膜重要的胞外多糖葡聚糖,葡聚糖一方面介导细菌蔗糖依赖的生物膜形成,另一方面当外源性糖源缺乏时,被降解供细菌继续代谢。因此可以通过控制葡萄糖基转移酶而控制龋病的发生发展。本文就变异链球菌葡萄糖基转移酶基因转录的调控因子作一综述。

Glucosyltransferase（GTF）is secreted by streptococcus mutans inhabited in the oral cavity.It synthesizes glucans which provide binding sites for a succession of bacteria on hard surfaces.Therefore,inhibition of formation and accumulation of cariogenic biofilm communities by affecting glucosyltransferase is an attractive route to prevent both dental caries.This article reviews the regulators of gene transcription of glucosyltransferase.