骨髓间充质干细胞膜片技术及应用的研究进展

Bone Marrow Mesenchymal Stromal Cells Sheet Technology and Its Application

骨髓间充质干细胞易于获得,贴壁生长,具备优良的成膜特性,是现代组织工程学中理想的种子细胞。由于具有良好的分化能力,骨髓间充质干细胞膜片被广泛地应用于组织再生工程。常用的骨髓间充质干细胞膜片包括单层细胞膜片、共培养细胞膜片、多层细胞膜片、三维培养细胞膜片、细胞膜片片段等。本文就近年来利用骨髓间充质干细胞构建细胞膜片的方法及其应用做如下综述。

Bone marrow mesenchymal stromal cells（BMSCs）were easy to obtain.The cells grew well with adherence and had good film forming ability.It was an ideal seed cell in modern tissue engineering technology.Because of its good differentiation ability,the BMSCs membrane was widely used in tissue regeneration.The common used BMSCs membranes included monolayered cell sheet,co-culture cell sheet,multilayered cell sheet,three-dimensional culture of cell sheet,cell sheet fragments,and etc.The aim of this article was to review the method of cell membrane construction of BMSCs and the application of BMSCs in tissue engineering.