摘要
胶质瘤是大脑最常见的原发恶性肿瘤.尽管通过规范化的治疗：包括最大范围的手术切除以及后续的放化疗,但是与其相关的发病率和病死率仍然较高,所以迫切的需要一种新的治疗手段.溶瘤病毒抗肿瘤的概念早在20世纪初期就被人提及,这是一类具有复制能力的肿瘤杀伤型病毒,人们发现肿瘤患者感染某些病毒后,肿瘤逐渐消退.随着分子生物学、免疫学、病毒学以及基因工程的发展,溶瘤病毒作为治疗肿瘤的新方法,越来越受到研究者们的关注.本文就溶瘤病毒的抗肿瘤原理及其在胶质瘤治疗中的临床应用做一概述.
Glioma is the most common primary malignant tumor in the brain.Although through standardized treatment,including the largest range of surgical resection and subsequent radiotherapy and chemotherapy,the morbidity and mortality is still high,so we need a new treatment.The oncolytic virus antitumor concept was mentioned in the early 20th century,which is a kind of antitumor virus,people found that cancer patients infected with certain viruses,the tumor was gradually disappeared.With the development of Molecular Biology,Immunology,Virology and Genetic Engineering,oncolytic virus becomes a new method of tumors treatment,which attracts more and more researchers＆#39; attention,so we made an overview in the antitumor principle of oncolytic virus and its clinical application in the treatment of glioma.
出处
《中国综合临床》
2017年第6期557-560,共4页
Clinical Medicine of China
