2013～2015年某三甲医院质子泵抑制剂使用情况分析

Utilization of the Proton Pump Inhibitors in a 3-A Grade Hospital from 2013 to 2015

目的:通过对某三甲医院2013~2015年质子泵抑制剂(Proton pump inhibitors,PPIs)使用情况分析,为临床合理用药及科学管理提供参考依据。方法:从医院信息系统调取2013~2015年医院PPIs的品种、规格、剂型、数量、销售金额等数据,进行评价分析。结果:2013~2015年医院PPIs总销售金额、总用药频度(defined daily dose system,DDDs)呈逐年增长趋势,销售金额及DDDs排序前3位的药品分别是注射用泮托拉唑钠、注射用兰索拉唑、雷贝拉唑钠肠溶胶囊,PPIs注射剂的销售金额及DDDs所占比重较高。埃索美拉唑镁肠溶片销售金额增长迅速。连续3年注射用埃索美拉唑钠限定日费用(defined daily cost,DDC)最高,其他药品的DDC呈平稳趋势,多数PPIs的排序比≥1.0。结论:2013~2015年医院PPIs临床使用基本合理,但存在临床倾向于使用注射剂和部分品种加重患者经济负担现象,需进一步加强和完善PPIs临床应用与管理。

Objective： To investigate the clinical use of proton pump inhibitors （PPIs） so as to provide reference for clinical rational use of PPIs in a 3-A grade hospital. Methods： The application data of PPIs in our hospital during 2013 - 2015, retrieved from hospital in- formation system including varieties, specification, dosage form, quantity, consumption sum ete were evaluated and analyzed. Results： The total sales amount and defined daily dose system （DDDs） increased year by year in our hospital from 2013 to 2015, pantoprazole for injection ,lansoprazole for injection and rabeprazole enteric capsules were ranked among the top three. The PPIs for injection took a great proportion in both DDDs and consumption sum. Sales of esomeprazole magnesium enteric-coated tablets were growing rapidly. DDC of es- omeprazole for injection was highest for three consecutive years and the DDC was stable for other drugs. The majority of ranking ratio were greater than or equal to I. Conclusion ： The use of PPIs in our hospital is on the whole rational, but the clinical tendency is to use PPIs for injection and partial varieties aggravate the patient＇s financial burden. We need to further strengthen and improve the clinical application and management of PPIs.