摘要
目的:比较不同糖耐量人群甲状腺结节的患病率,探讨胰岛素抵抗与甲状腺结节患病率的关系。方法:收集2型糖尿病组(T2DM)342例,糖耐量正常组(NGT)145例,糖调节异常组(IGR)180例,完善病史、体格检查、血生化、甲状腺功能、甲状腺超声等,比较三组间甲状腺结节检出率、HOMA-IR及Matsuda指数;根据有无甲状腺结节,分为结节组和非结节组,比较两组间性别、年龄、BMI、HOMAIR、Matsuda指数及相关性。结果:T2DM组甲状腺结节患病率明显高于IGR组及NGT组,且差异有统计学意义(P<0.05);T2MD组BMI、HOMA-IR、TSH明显高于其他两组,差异有统计学意义(P<0.05),与此同时,T2DM组的Matsuda指数低于其他两组。甲状腺结节组的BMI、FPG、HOMA-IR较非甲状腺结节组增高,差异具有统计学意义,P<0.05;结节组Matsuda指数低于非结节组,P<0.05。对甲状腺结节进行Logistic回归分析,结果显示甲状腺结节与年龄、BMI、空腹血糖、HOMA-IR呈正相关(OR分别为1.061、1.121、1.114、1.225,95%CI分别为1.015~1.079、1.057~1.324、1.142~1.416、1.112~1.428),与Matsuda指数呈负相关(OR为0.385,95%CI分别为0.298~0.479)。结论:糖尿病人群中甲状腺结节患病率明显升高,年龄、性别、空腹血糖、BMI及胰岛素抵抗是甲状腺结节患病的独立危险因素。
Objective: To compare the prevalence of thyroid nodules among people with different glucose tolerance,and to investigate the relationship between insulin resistance and the incidence of thyroid nodules.Methods: three groups of subjects were collected in this study,342 patients with type 2 diabetes( T2DM),145 normal glucose tolerance( NGT),and 180 patients with impaired glucose regulation( IGR),to compare between the three groups of thyroid nodule detection rate,HOMA-IR and Matsuda index. Divided into the nodules group and non-nodules group,and compared the differences between the two groups of gender,age,BMI,HOMA-IR and Matsuda index and correlation. Results: Thyroid nodules prevalence in T2 DM group was significantly higher than in IGR and NGT group( P〈0.05); At the same time,the BMI,HOMA IR and TSH levels in T2 DM group were higher than the other two groups( P〈0.05); The Matsuda index of T2 DM group was lower. The BMI,FPG,HOMA-IR in Thyroid nodule group were higher than those in non-nodules group,P〈0.05; While the Matsuda index is lower than the non-nodule group,P〈0.05. Logistic regression analysis was carried out on the thyroid nodules,and the results showed that thyroid nodule and age,BMI,fasting glucose,HOMA-IR were positively correlated( OR = 1.061,1.121,1.114,1.225,95% CI = 1.015 - 1.079,1.057 - 1.324,1. 142 - 1. 416,1. 112 - 1. 428),and negatively correlated with Matsuda index( OR = 0.385,95%CI = 0.298 - 0.479). Conclusion: The prevalence of thyroid nodules significantly is higher in the diabetic population,age,gender,fasting glucose,BMI and insulin resistance are independent risk factors for the development of thyroid nodules disease.
作者
上官海燕
郭雯
欣冰
李杰
王亚梅
罗倩
SHANGGUAN Haiyan GUO Wen XIN Bing et al(Nanjing Central Hospital, Jiangsu Nanjing 200018, China)
出处
《河北医学》
CAS
2017年第7期1101-1104,共4页
Hebei Medicine
基金
南京卫生局基金项目
(编号:YKK15229)