公民逝世后捐献肾脏的质量评估

Assessment of the kidney from donation after citizen's death

准确评估公民逝世后捐献肾脏的质量,可以避免供肾浪费,减少术后移植肾功能延迟恢复或移植肾原发性无功能的发生。目前临床通常对供肾进行肉眼大体观察、供者危险评分,有选择性地进行供肾活检,并结合肾脏低温机械灌注参数,以及供者血液、尿液和灌注液的分子诊断和生物标志物检测结果进行综合判定。尽管有多种评估技术,但仍无法精确评估供肾质量。当前,我国公民逝世后器官捐献案例正在快速增长中,亟待制订统一的标准来指导全国捐献器官的质量评估,推动其在临床上更规范、有效、安全地应用。

Accurate assessment of the kidney from donation after citizen＇s death,can avoid the waste of the donor kidney,reduce the incidence of postoperative delayed graft function or renal allograft primary nonfunction. Naturally,donor kidney will be examined through visual observation,donor risk score,selective renal biopsy,parameters of hypothermic machine pefusion,as well as comprehensive judgement on molecular diagnosis,and biomarker detection for blood,urine and perfusion solution.However,accurate quality assessment of donor kidney has get to be improved. At present,organ donation after citizen＇ s death in China is growing rapidly. It is very necessary to formulate unified quality assessment standards to guide the national organ donation,and promote the more standardized,effective and safe clinical application.