摘要
Quorum sensing is a mechanism in which bacteria coordinate the expression of certain genes in response to their population density.Many marine vibrios are important pathogens in aquaculture and many pathogenic vibrios are found to control the expression of virulence factors by quorum sensing system. The frequent use of antibiotics is leading to the rapid development of resistance. There is an urgent need to develop alternative ways to control infections caused by bacterial pathogens in aquaculture.Disruption of bacterial quorum sensing has been proposed as a new anti-infective strategy. This article summarize the quorum sensing systems in marine vibrios, the modes of signal interference and their potential applications in aquaculture.
Quorum sensing is a mechanism in which bacteria coordinate the expression of certain genes in response to their population density.Many marine vibrios are important pathogens in aquaculture and many pathogenic vibrios are found to control the expression of virulence factors by quorum sensing system. The frequent use of antibiotics is leading to the rapid development of resistance. There is an urgent need to develop alternative ways to control infections caused by bacterial pathogens in aquaculture.Disruption of bacterial quorum sensing has been proposed as a new anti-infective strategy. This article summarize the quorum sensing systems in marine vibrios, the modes of signal interference and their potential applications in aquaculture.
出处
《海洋科学集刊》
CAS
2007年第1期153-165,共13页
Studia Marina Sinica
基金
教育部新世纪优秀人才支持计划(NCET-04-0646)
教育部留学回国人员科研启动基金
