肺神经内分泌肿瘤患者预后影响因素分析

Factors influencing the prognosis in patients with pulmonary neuroendocrine tumors

目的探讨影响肺神经内分泌肿瘤患者预后的因素。方法回顾性分析2001年12月至2013年12月间福建省肿瘤医院收治的71例肺神经内分泌肿瘤患者的临床资料,其中,资料完整患者54例。使用COX单因素和多因素回归分析法,探讨患者临床治疗特征和治疗方法对生存期的影响。结果单因素分析显示年龄、肿瘤分期、淋巴转移情况、组织学类型和治疗方法是影响患者预后的因素。多因素分析显示淋巴转移、肿瘤分期和治疗方法是影响患者生存期的独立因素。结论手术治疗是肺神经内分泌肿瘤患者首选治疗方式,但淋巴转移和肿瘤分期会影响患者生存期。

Objective To explore the factors that influence the prognosis of pulmonary neuroendo- crine tumors. Methods A retrospective analysis of 71 patients with pulmonary neuroendoerine tumors trea- ted at Fujian Provincial Cancer Hospital from December 2001 to December 2013 were conducted. Among them, 54 patients had complete data. Using Cox univariate and multivariate regression analysis, the effect of theraputic features and strategies on survival was discussed. Results Univariate analysis showed that age, tumor stages, lymph node metastasis, histological type and treatment regimens were factors influencing the prognosis. Multivariate analysis showed that lymph node metastasis, tumor stages and treatment regimens were independent factors influencing the survival. Conclusion Surgery is the preferred therapy for pulmo- nary neuroendocrine tumors but the lymph node metastasis and tumor stages have an effect on the survival.