靶向药物靶点蛋白在三阴性乳腺癌中的表达及临床意义

Expression and clinical significance of drug targeted protein in triple-negative breast cancer

目的探讨靶向药物靶向蛋白在三阴性乳腺癌组织中的表达及临床意义。方法选取2011年1月至2015年12月间成都市第七人民医院收集的72例三阴性乳腺癌术后组织标本(三阴性组)和90例非三阴性乳腺癌组织标本(非三阴性组),采用免疫组化染色检测两组标本中靶向蛋白血管内皮生长因子(VEGF)、p53和基质金属蛋白酶9(MMP-9)的表达情况,并分析三阴性乳腺癌组织中三种蛋白的表达及其临床意义。结果三阴性组患者组织标本中p53、VEGF和MMP-9的阳性表达率均显著的高于非三阴性组患者,差异有统计学意义(P<0.05)。三阴性乳腺癌患者组织标本中p53和MMP-9阳性表达与患者的组织学分级和淋巴结转移具有显著的相关性,差异有统计学意义(P<0.05)。VEGF阳性表达与三阴性乳腺癌患者临床病理特征的关系不明显,差异无统计学意义(P>0.05)。结论靶向蛋白在三阴性乳腺癌组织中表达较高,p53和MMP-9的表达与患者的临床病理特征有关。

Objective To explore the expression and clinical significance of drug targeted protein in triple-negative breast cancer. Methods Select tissue specimen from 72 patients with triple-negative breast cancer and 90 patients with non-triple-negative breast cancer at Chengdu Seventh People＇s Hospital from January 2011 to December 2015. Using immunohistoehemistry staining, the expression of vascular en- dothelial growth factor （VEGF） , p53, matrix metalloproteinase-9 （MMP-9） were detected and the expres- sion and clinical significance of these three proteins in triple-negative breast cancer tissues were analyzed. Results The positive expression of p53, VEGF and MMP-9 protein was significantly higher in tissue sam- ples of patients with triple-negative breast cancer than in patients with non-triple-negative breast cancer （P 〈0. 05）. In triple-negative breast cancer, positive expression of p53 protein and MMP-9 protein was significantly associated with histological grade and lymph node metastasis （ P 〈 0.05 ）. The relationship be- tween the expression of VEGF protein and the pathological characteristics was not statistically significant in patients with triple-negative breast cancer （ P 〉 0. 05 ）. Conclusion The expression of target proteins was significantly high in patients with triple negative breast cancer and the expression of p53 and MMP-9 was significantly associated with clinicopathological features.