止嗽散联合西药治疗外感顽固性咳嗽随机平行对照研究

Zhisousan combined Western Medicine Treatment of Exogenous Random Parallel Control Study in Intractable Chronic Cough

[目的]观察止嗽散联合西药治疗外感顽固性咳嗽疗效。[方法]使用随机平行对照方法,将200例住院及门诊患者按随机数字表方法简单随机分为两组。对照组100例头孢克肟,100mg/次,2次/d,口服;氨溴索,10mL/次,3次/d,口服;氯苯那敏,8mg/次,3次/d,口服。治疗组100例止嗽散:荆芥、紫菀炙、百部炙、桔梗、陈皮、甘草各12g,川贝母10g,麻黄炙8g;咽痒重加虫蜕、千张纸、姜虫各10g;咳声清高、胸闷及胸痛重加海合壳、青黛及瓜壳各10g;口干、口苦重加黄芩、芦根、沙参各10g;痰多、痰黄重加竹黄、浙贝母各10g;咽部如梗重加复花、射干10g;咽喉壁滤泡增生加丹参、白芥子各10g;水煎150mL,加蜂蜜30mL,1剂/d,早中晚分服;西药治疗同对照组。连续治疗7d为1疗程。观测临床症状、肺部呼吸音、不良反应。治疗1疗程(7d),判定疗效。随访6个月,观测复发率。[结果]治疗组显效72例,有效23例,无效5例,总有效率95.00%;对照组显效25例,有效57例,无效18例,总有效率82.00%;治疗组疗效优于对照组(P<0.01)。[结论]止嗽散加味联合西药治疗外感顽固性咳嗽,疗效满意,无严重不良反应,值得推广。

[Objective] Observation of Zhisousan combined with western medicine in the treatment of exogenous treatment of intractable cough. [Method] Using random parallel control method, 200 patients were randomly divided into two groups according to the random number table method. The control group of 100 cases of cefixime, 100 rag/times, 2 times/d, oral; ambroxol, 10 mL/times, 3 times/d, oral; chlorpheniramine, 8 mg/times, 3 times/d, oral. The treatment group of 100 cases of Zhisousan： Schizonepeta, aster broil, Stemona broil, Platycodon root, tangerine peel, licorice 12g, Fritillaria 10g, ephedra sunburn 8g; pharyngeal itching with exuvium, 1000 paper, ginger worm 10g; cough, chest tightness and chest pain with lofty neptune shell, and indigo melon the shell of 10g; dry mouth, mouth bitter and scutellaria root, reed rhizome, radix 10g; phlegm, phlegm and yellow tabasheer, Zhejiang Fritillaria 10g; stem with complex such as pharyngeal flower, Belamcanda 10g; throat wall follicular hyperplasia and Salvia miltiorrhiza and white mustard by 10g; Decoction 150mL, honey 30mL, agent l/d, early in the evening service; western medicine treatment with the control group. Continuous treatment for 1 courses of 7d. Observation of clinical symptoms, pulmonary respiratory sound, adverse reactions. Treatment of 1 courses of treatment （7d）, determine the efficacy. After 6 months follow-up, the recurrence rate was observed. [Result] The treatment group 72 cases, effective 23 cases, invalid 5 cases, total effective rate 95%; control group 25 cases, effective 57 cases, invalid 18 cases, total effective rate 82%; treatment group than the control group （P〈0.01）. [Conclusion] Modified Zhisousan combined with western medicine by the treatment of intractable cough, curative effect, no serious adverse reactions, worthy of promotion.