冠心病患者血清铁蛋白、总铁结合力、血清铁蛋白/总铁结合力水平与冠状动脉病变及心血管事件的关系

The relationship of SF,TIBC,SF/TIBCs levels with coronary artery disease and cardiovascular events in patients with coronary heart disease

目的探讨血清铁蛋白(SF)、总铁结合力(TIBC)、SF/TIBC水平与患者冠状动脉病变的关系及其对心血管事件的预测价值。方法选择2011年6月-2013年6月行冠状动脉造影确诊为冠心病的60例患者做为研究对象,检测患者铁代谢相关指标(SF、TIBC、SF/TIBC),探讨其与患者冠状动脉病变的关系,并对所有患者均定期进行随访,记录患者心血管事件发生情况,采用Logistic回归模型探讨心血管事件的风险因素。结果多支病变患者SF、SF/TIBC水平高于单支及双支病变患者,而TIBC水平低于单支及双支病变患者;完全闭塞组患者SF、SF/TIBC水平高于轻度、中度、重度狭窄患者;而TIBC水平低于轻度、中度、重度狭窄患者,上述差异均有统计学意义(P<0.05)。冠脉狭窄和冠脉病变支数与SF、SF/TIBC均呈正相关(r值分别为0.24、0.14和0.36、0.29,P<0.05),与TIBC呈负相关(r值分别为-0.47和-0.64,P<0.05)。SF/TIBC、冠脉狭窄、冠脉病变支数是患者心血管事件的独立风险因素(P<0.05)。结论冠脉病变支数及狭窄程度均与SF、TIBC、SF/TIBC水密切相关,SF/TIBCs是冠心病患者心血管事件的独立风险因素。

Objective To investigate the relationship of serum ferritin（ SF）,total iron binding capacity（ TIBC）,SF/TIBCs patients with coronary artery disease and the predictive value of cardiovascular events. Methods 60 patients with coronary heart disease patients were confirmed by coronary artery angiography and selected from June 2011 to June 2013,iron metabolism related indicators（ SF,TIBC,SF/TIBCs） were detected and its relationship with coronary artery lesions in patients were explored.All patients were followed up regularly,and the cardiovascular events of patients were recorded,using logistic regression model to analyze the risk factors of cardiovascular events. Results The levels of SF and SF/TIBC were higher in patients with multiple vessel disease than in patients with single or double vessel disease,while TIBCs was lower than that in patients with single or double vessel disease. SF and SF/TIBC levels in complete occlusion group were higher than those in patients with mild,moderate and severe stenosis,but TIBCs was significantly lower than those with mild,moderate and severe stenosis,and the differences were statistically significant（ P 〈0. 05）. Coronary artery stenosis and coronary lesion vessels were positively correlated with SF,SF/TIBC（ r = 0. 24,r = 0. 14,r = 0. 36,r = 0. 29,P〈 0. 05）; coronary artery stenosis and coronary lesion vessels were negative correlation with TIBC（ r =-0. 47,r = 0. 64,P 〈0. 05）. SF/TIBC,coronary artery stenosis,coronary angiography are independent risk factors for cardiovascular events in patients（ P 〈0. 05）. Conclusion The number of diseased coronary artery and the degree of stenosis are closely related with SF,TIBC,SF/TIBCs water,and SF/TIBCs is an independent risk factor for cardiovascular events in patients with coronary heart disease（ CHD）.