陕西省不同社会人口学特征的男男性行为者5年HIV新发感染率监测分析

Monitoring and analysis of HIV recent infection rate in MSM with different social demographic characteristics in Shaanxi during the recent 5 years

目的估算陕西省不同社会人口学特征的男男性行为者(MSM)2011年-2015年HIV新发感染率。方法陕西省5年监测MSM共4 609例纳入研究,HIV抗体确证阳性样本使用BED捕获酶联免疫法(BED)进行新发感染检测,按照社会人口学特征分层分析MSM新发感染率。结果 2011年-2015年陕西省MSM HIV新发感染率分别为5.00%、6.50%、4.52%、5.78%和4.49%。5年间HIV抗体阳性率和新发感染率差异无统计学意义(χ2值分别为7.389、0.031,P>0.05)。单因素分析显示,未婚的监测对象HIV新发感染率高于已婚及其他婚姻状态(OR=1.807),西安市的监测对象HIV新发感染率高于宝鸡市(OR=3.780)。多因素Logistic分析,地区是HIV抗体阳性(OR=2.900)和新发感染(OR=3.543)的影响因素(P<0.05),西安地区的MSM较宝鸡地区的MSM HIV抗体阳性和新发感染的危险性高。结论陕西省MSM HIV新发感染率较高,5年间疫情流行水平稳定,应针对低年龄段、高学历、未婚及西安市的MSM采取有效干预措施。

Objective To estimate the recent infection rate of HIV among men who have sex with men（ MSM） with different social demographic characteristics in Shaanxi province during 2011-2015. Methods A total of 4 609 MSM were monitored and collected to detect human immunodeficiency virus（ HIV） antibody. BED HIV capture enzyme immunoassay（ BED） was employed to detect recent infections as if the HIV antibody was positive,and then the rate of recent infection was estimated.Results The recent HIV infection rates were respectively 5. 00%,6. 50%,4. 52%,5. 78% and 4. 49% from 2011 to 2015 in MSM. The differences in the positive rate of HIV antibody and the recent infection rate showed no statistical significance（ χ2= 7. 389,χ2= 0. 031,P〉 0. 05）. Univariate analysis showed that the HIV recent infection rate of unmarried monitoring objects was higher than the married and other marital status（ OR = 1. 807）,and that of the monitoring objects in Xi＇an was higher than that of Baoji（ OR = 3. 780）. Multiple logistic regression analysis showed that area was related with HIV infection（ OR =2. 900） and recent infection（ OR = 3. 543,P〈 0. 05）. HIV antibody positive and the risk of new infections were higher in MSM of Xi＇an than that of Baoji. Conclusion The HIV recent infection rate in MSM was at a high level in Shaanxi,the overall prevalence level was stable in the 5 years. It is necessary to take effective interventions in MSM who are in younger age,high education,unmarried status in Xi＇an.