胚胎停育环境行为危险因素的病例对照研究

Embryo growth arrest-related environmental and behavioral risk factors:a case-control study

目的探讨胚胎停育患者在生活和工作中的环境行为危险因素。方法采用病例-对照研究对192例胚胎停育患者和192例正常妊娠者进行问卷调查,内容包括研究对象一般情况、生活和工作中的可疑环境行为危险因素等。结果经多因素非条件logistic回归分析,结果显示,年龄大(OR=1.064,95%CI:1.005~1.126)、孕前3个月或孕期吸入二手烟(OR=2.185,95%CI:1.028~4.644)、使用染发剂(OR=2.780,95%CI:1.328~5.821)、居室装修(OR=3.258,95%CI:1.813~5.856)是胚胎停育的危险因素,教育程度高(OR=0.668,95%CI:0.523~0.852)、孕前健康状况良好(OR=0.184,95%CI:0.078~0.435)、主动获取优生知识(OR=0.494,95%CI:0.265~0.920)、孕期情绪状况愉快(OR=0.496,95%CI:0.291~0.845)、孕期与家庭成员关系和睦(OR=0.475,95%CI:0.241~0.934)是胚胎停育的保护因素。结论年龄大、孕前3个月或孕期吸入二手烟、使用染发剂、居室装修可能与胚胎停育的发生有关系,而教育程度高、孕前健康状况良好、主动获取优生知识、孕期情绪状况愉快、孕期与家庭成员关系和睦则可以减少胚胎停育发生。

Objective To investigate the potential risk factors related to the induction of embryo growth arrest in living and working environment. Methods A case-control study was conducted. A total of 192 cases who were diagnosed with embryo growth arrest were selected as the case group,a total of 192 normal pregnant women or normal parturition within seven days were selected as the control group. The basic information,risk factors related to the induction of embryo growth arrest in living and working environment were investigated. Results Multi-factor unconditioned logistic regression analysis showed that older in age（OR =1.064,95% CI： 1.005-1.126）,exposure to secondhand smoke three months before or during pregnancy（OR =2.185,95% CI：1.028-4.644）,the use of hair dyes（OR=2.780,95%CI： 1.328-5.821）,bedroom decoration（OR=3.258,95%CI：1.813-5.856） were risk factors for embryo growth arrest. However higher education degree（OR=0.668,95%CI： 0.523-0.852）,pre-pregnancy in good health（OR=0.184,95%CI： 0.078-0.435）,the initiative to obtain knowledge of healthy birth（OR=0.494,95%CI： 0.265-0.920）,a happy emotional state during pregnancy（OR=0.496,95%CI： 0.291-0.845）,harmonious relations with family members during pregnancy（OR =0.475,95% CI： 0.241-0.934） were protective factors for embryo growth arrest.Conclusion The older in age,exposure to secondhand smoke three months before pregnancy or during pregnancy,the use of hair dyes,bedroom decoration may be involved in embryo growth arrest,while higher level of education,pre-pregnancy in good health,the initiative to obtain knowledge of healthy birth,a happy emotional state during pregnancy and harmonious relations with family members during pregnancy may reduce the embryo growth arrest.