急性脑梗死合并脑白质疏松的危险因素分析

Risk factors of patients with acute cerebral infarction complicated with leukoaraiosis

目的探讨急性脑梗死合并脑白质疏松(leukoaraiosis,LA)发生的危险因素。方法选取急性脑梗死患者207例,按是否合并LA分为合并LA组93例,未合并LA组114例,收集两组患者年龄、高血压、脑梗死史、HCY、hs CRP、性别、吸烟史、饮酒史、糖尿病、高脂血症、冠心病等临床资料,分别采用单因素分析及多因素Logistic回归分析对以上可能的危险因素进行分析。结果 (1)单因素分析:LA组与无LA组比较,年龄、高血压、脑梗死史、HCY、hs CRP差异有统计学意义(P<0.05),性别、吸烟史、饮酒史、糖尿病、高脂血症、冠心病比较无统计学差异。(2)多因素Logistic回归分析:年龄、高血压、脑梗死病史、HCY、hs CRP为LA发生的危险因素(P<0.05)。结论年龄、高血压、脑梗死病史、HCY、hs CRP与LA发生有关;性别、吸烟史、饮酒史、糖尿病、高脂血症、冠心病与LA发生无关。

Objective To study the risk factors of acute cerebral infarction in patients with leukoaraiosis （LA） and without leukoaraiosis （ LA）, and to explore the possible risk factors of LA. Methods Two hundred and seven patients of acute cerebral infarction, with or without LA, were divided into LA group （n =93） and non-LA group （n = 114）. Clinical data was collected on age, hy- pertension, cerebral infarction, HCY, hsCRP, sex, smoking history, drinking history, diabetes, hyperlipidemia, and coronary heart disease of these patients. Logistic single-factor and multi-factor regression analysis was used to identify the risk factors. Results （ 1 ） Single-factor analysis suggested that there was statistically significant difference between LA group and non-LA group in age, hypertension, cerebral infarction, HCY and hsCRP （ P 〈 0.05）, but not in gender, smoking history, drinking history, diabetes, hyperlipidemia or coronary heart disease. （2） Multivariate logistic regression analysis indicated that age, hypertension, history of cerebral infarction, HCY and hsCRP were risk factors of LA （ P 〈 0.05 ）. Conclusions Age, hypertension, cerebral infarction, HCY and hsCRP are possibly associated with leukoaraiosis.