原发性干燥综合征合并Ⅰ型肾小管酸中毒继发低血钾性麻痹的临床特点

Characteristics of hypokalemic paralysis secondary to type 1 renal tubular acidosis in primary sjogren syndrome

目的探讨原发性干燥综合征合并Ⅰ型肾小管酸中毒继发低血钾性麻痹的临床特点。方法对18例原发性干燥综合征合并Ⅰ型肾小管酸中毒继发低血钾性麻痹患者临床资料进行回顾性分析,总结其临床特点。结果 11例以低血钾性麻痹为首发症状,7例以眼干、口干为首发症状。18例均表现为发作性四肢无力,10例出现代谢性骨病,其中9例诊断骨质疏松,1例诊断骨软化症。结论原发性干燥综合征合并Ⅰ型肾小管酸中毒继发低血钾性麻痹有典型临床表现,早期诊断可以早治疗。

Objective To explore the clinical features of hypokalemic paralysis secondary to type 1 renal tubular acidosis in primary sjogren syndrome.Methods We retrospectively studied eighteen cases of hypokalemic paralysis secondary to type 1 renal tubular acidosis in primary sjogren syndrome.Results The clinical manifestations of hypokalemic paralysis secondary to type 1 renal tubular acidosis preceded the development of sicca syndrome in eleven cases of primary sjogren syndrome. In the other seven cases, the prodromal symptoms were oral dryness （xerostomia） and dryness of eyes （kerato conjunctivitis sicca）. All the eighteen cases had hypokalemic paralysis. Among the ten cases of bone disease, nine had osteoporosis, and one had osteomalacia.Conclusions Patients with hypokalemic paralysis secondary to renal tubular acidosis in primary sjogren syndrome have typical clinical features and early diagnosis can lead to proper treatment .