纳米材料靶向肿瘤相关巨噬细胞用于肿瘤成像及治疗的研究进展

Advances in nanoparticle-targeting tumor associated macrophages for cancer imaging and therapy

肿瘤组织由肿瘤细胞和复杂的微环境构成。肿瘤相关巨噬细胞(TAM)是肿瘤微环境的重要组成成分,在肿瘤生长转移及微环境调控中扮演着重要的角色。近年来的研究表明,纳米材料作为新兴的技术平台,为肿瘤的成像和治疗提供了新的思路。一方面可以通过TAM成像为肿瘤发生、发展以及肿瘤治疗的效果提供直观的证据;另一方面通过TAM靶向杀伤或者促进TAM类型转化,调节肿瘤微环境的免疫抑制,提高肿瘤治疗效果。本文阐述了TAM的功能,同时对靶向TAM的纳米材料在肿瘤成像以及治疗方面的应用进行了综述。

Tumor tissues are composed of tumor cells and complicated microenvironment. Tumor associated macrophages （TAMs） as an important component in tumor microenvironment, play fundamental roles in tumor progression, metastasis and microenvironment regulation. Recently, studies have found that nanotechnology, as an emerging platform, provides unique potential for cancer imaging and therapy. With the nanotechnology, TAMs imaging presents direct evidence for cancer development,progression, and the effectiveness of cancer treatments; it also can regulate the immunosuppression of tumor microenvironment and improve therapeutic efficiency through TAMs targeted killing or phenotypic transformation. In this article, we illustrate the function of TAMs and review the latest development in nano-carriers and their applications in tumor associated macrophage targeting cancer imaging and therapy.