表观健康人群血脂分布特点分析

Analysis of Blood Lipid Distribution of Apparently Healthy People

目的观察表观健康人群血脂含量与年龄和性别的关系,分析血脂与载脂蛋白的相关性,为建立血脂参考范围和预防心血管疾病提供科学依据。方法采用贝克曼AU5421全自动生化分析仪对5701名20~60岁的表观健康体检者进行TC、HDL-C、LDL-C、TG、LP(a)、ApoAI和ApoB的测定,同时收集年龄和性别信息,对数据进行趋势检验和相关性分析。结果血脂四项随年龄呈单向变化(P<0.01),TC、LDL-C和TG血清含量随年龄递增,HDL-C随年龄递减,在男女分层和总人群中,血脂含量随年龄的变化趋势一致。血脂四项在不同性别间存在显著性差异(P<0.01),男性TC、LDL-C和TG血清含量高于女性,HDL-C含量低于女性。相关分析发现,TC、LDL-C和ApoB呈强的正相关(r>0.7,P<0.01),HDL-C与ApoAI也存在强的正相关(r>0.7,P<0.01)。结论表观健康人群具有血脂增龄现象,血脂含量在不同性别间存在显著差异,提示临床建立参考范围时应考虑年龄和性别因素的影响。同时发现载脂蛋白与血脂含量具有很强的相关性,载脂蛋白有可能成为心血管疾病发病风险的预测指标。

Objective To investigate the clinical features, treatment status and prognosis of patients with heart failure in different grade of hospitals in China. Method From December 2012 to November 2014 a total of 990 consecutive outpatient or inpatient with heart failure in 24 hospitals with different grades, spread in different regions in China were enrolled. Data on demography comorbidities, diagnosis and therapy were collected. Patients were followed for one year. The end points were all-cause mortality, rehospitalization due to heart failure and these composite endpoint events. Results The average age of the patients was 65.6±13. l years old and 57.2% were male. Outpatients accounted