红细胞水平与脑出血患者全因死亡相关

The Levels of Red Blood Cells are Associated with All-cause Mortality of Intracerebral Hemorrhage Patients

目的本研究的目的旨在分析脑出血患者红细胞(RBC)水平与全因死亡的相关性。方法我们纳入了2000年至2001年共479例脑出血患者并平均随访3.7年,其中男性298例(62.2%),平均年龄(58.6±9.8)岁。根据患者入院时红细胞浓度四分位值将患者分为四组,即RBC数量第1分位(RBC≤4.0×10^(12)/L)组(Q1组,n=114),RBC数量第2分位(4.0<RBC≤4.4×10^(12)/L)组(Q2组,n=114),RBC数量第3分位(4.4<RBC≤4.8×10^(12)/L)组(Q3组,n=132),RBC数量第4分位(RBC>4.8×10^(12)/L)组(Q4组,n=119)。收集患者入院的基线资料及静脉血标本,分析各项指标,终点事件定义为全因死亡。结果 479例脑出血患者总全因死亡率为22.1%(110/479)。以Q1组为基准进行计算,Q2组(13.2%,15/114)、Q3组(15.2%,20/132)组患者全因死亡率低于Q1组(26.3%,30/114),差异均有统计学意义(P<0.05),但是Q4组(31.1%,37/119)患者全因死亡率与Q1组(26.3%,30/114)相比无统计学意义(P>0.05)。在调整了年龄,性别等影响预后因素后,Q2(HR=0.439,95%CI=0.227-0.851,P=0.015)、Q3(HR=0.506,95%CI=0.273-0.936,P=0.030)较Q1组均对脑出血患者全因死亡具有保护作用,而Q4(HR=1.047,95%CI=0.596-1.840,P=0.872)与Q1组相比差异没有统计学意义。结论红细胞水平与脑血栓患者全因死亡相关。

Objective The purpose of this study was to investigate the relationship between RBC levels and all-cause mortality in intracerebral hemorrhage patients. Methods A total of 479 intracerebral hemorrhage patients were recruited during 2000-2001 and prospectively followed up for a median of 3.7 years. There were 298 （62.2%） male and the average age were （58.6±9.8）. According to admission RBC quantities, the patients were divided into 4 groups： Q 1 group, RBC quantity（RBC≤4.0×10^12/L, n= 114）, Q2 group, RBC quantity（4.0〈RBC≤4.4×10^2/L）, n=114, Q3 group, RBC quantity（4.4〈RBC≤4.8×10^12/L）, n=132, Q4 group, RBC quantity（RBC〈4.8×10^12/L）, n-119. The basic information was collected in all groups, the primary endpoint was all-cause mortality. Results The total all-cause mortality in the 479 patients with intracerebral hemorrhage was 22.1% （110/479）. Q I group was calculated to be set as a reference. The all-cause mortality in Q2 （13.2%, 15/114） and Q3 （15.2%, 20/132） group were lower than that in Q1（26.3%, 30/114）group, the difference was statistically significant （P 〈0.05）, but the all-cause mortality in Q4 （31.1%, 37/119） group was no significant difference to that in Q1（26.3%, 30/114） group（P〉 0.05）. With adjusted age, gender and other relevant factors, compared with Q1, Q2（HR=0.439,95%CI-0.227-0.851,P=0.015）, Q3（HR-0.506,95%CI=0.273-0.936, P〈0.030）groups played a protective role on all-cause mortality in cerebral thrombosis patient ,but The risk of death in Q4 group （HR-1.047,95%CI-0.596-1.840,P-0.872）was higher than QI group. Conclusions The levels of red blood cells were associated with all-cause mortality of intracerebral hemorrhage patients.