对氧磷酶1基因Q192R多态性与中国人冠心病关联的荟萃分析

Meta-analysis between the Q192R Polymorphism of Paraoxonase 1 Gene and Susceptibility to Coronary Artery Disease in Chinese Population

目的评估中国人群对氧磷酶1(paraoxonase-1,PON1)基因Q192R多态性与冠心病的关联性。方法通过检索中英文数据库,入选2017年1月以前在公开刊物上发表的病例对照研究,采用荟萃分析方法分别在显性和隐性遗传模式下计算合并比值比(OR值),95%CI作为研究效应合并指标。结果纳入文献16篇,共计4676例冠心病患者和5384例对照,显性遗传模式(RR+QR)/QQ合并OR=1.26(95%CI:1.04–1.54,P=0.021),隐性遗传模式RR/(QR+QQ)合并OR=1.20(95%CI:1.03–1.40,P=0.021)。但结果之间存在显著的异质性。基于3项大样本(n≥500冠心病患者)关联研究的结果,合并OR=1.27(95%CI:1.05-1.54,P=0.013),且异质性消失。结论中国人群PON1基因Q192R多态性与冠心病易感性之间存在弱阳性关联。

Objective To evaluate the association between the polymorphism of PONl gene Q 192R and risk of coronary artery disease （CAD） in Chinese population. Methods Association studies （published before January I, 2017） were identified by searching English and Chinese extensively. Both the dominant and recessive genetic models were used to calculate the pooled effects （odds ratios （OR） together with 95% CI）. Results Sixteen eligible original articles including a total of 4,676 patients with CAD and 5,384 controls. Under the dominant model, the pooled OR was 1.26 （95% CI： 1.04-1.54, P=0.021）. Under the recessive model, the pooled OR of 1.20 （95% CI： 1.03-1.40, P=0.021）. However, significant heterogeneity was tbund among the studies. Subgroup analysis indicated when studies were restricted to those with cases sample 〉500, the heterogeneity was significantly reduced and the association was still significant （pooled OR=1.27, 95% CI： 1.05-1.54, P=0.013）. Conclusion Our findings suggest that, in the Chinese population, the Q I92R polymorphism of PONl is associated with increased susceptibility to CAD.