葡萄糖依赖性促胰岛素释放多肽/胰高血糖素样肽-1与天然产物的研究进展

Research advances in glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 and natural products

近年来研究表明,肠道激素可通过一系列信号通路改善糖尿病患者的糖脂代谢紊乱,从而改善2型糖尿病患者的发病情况。肠道激素中对糖、脂代谢产生重要调节作用的主要依赖于葡萄糖依赖性促胰岛素释放多肽(GIP)及胰高血糖素样肽-1(GLP-1)2种激素,两者皆以葡萄糖依赖性的方式分泌,并极少发生低血糖风险,因而受到极大的关注,成为近年来2型糖尿病药物研究的热点。本文就相关天然产物对这2种激素的调节作用作一概述。

In recent years, increasing studies have shown that gut hormones can improve the glucolipid me- tabolism disorder by a series of signaling pathways, thus meliorating the onset of type 2 diabeties. The effect of gut hormones on glucolipid metabolism without obvious occurrence of hypoglycemia mainly depends on glucose-dependent insulinotropic polypeptide （GIP） and glucagon-like peptide-1 （GLP-1）, both of which are released in a glucose-dependent manner. Therefore, gut hormones attract more and more attention and become a hot spot in antidiabetic agents. In this paper, the influence of natural products on GIP/GLP-1 level is reviewed.