应用地诺前列酮栓治疗足月胎膜早破孕妇的临床疗效观察

The study in clinical effect of Dinoprostone Suppositories in premature rupture of membranes to full term pregnant women

目的探讨应用地诺前列酮栓治疗足月胎膜早破孕妇的临床疗效。方法选取2015年10月至2016年8月重庆市沙坪坝区妇幼保健计划生育服务中心收治的150例存在引产指征的足月妊娠孕妇作为研究对象,其中胎膜早破100例,未破膜50例(B组)。将100例胎膜早破孕妇根据治疗方式不同分为A组与C组,各50例。A组与B组均使用地诺前列酮栓引产,C组使用缩宫素引产。比较3组孕妇基本资料;记录孕妇宫颈完全成熟、阴道分娩率及剖宫产发生情况;并统计孕妇产褥感染情况及新生儿情况。结果 A组和B组孕妇宫颈完全成熟率均显著高于C组,差异有统计学意义(χ~2=11.11,P<0.01);A、B两组孕妇阴道分娩率差异无统计学意义(P>0.05),而与C组相比则显著升高(χ~2=11.98,P<0.01;χ~2=6.25,P<0.05);A组和B组胎儿窘迫发生率均显著低于C组,差异有统计学意义(χ~2=5.69,P<0.01);A、B两组孕妇产褥感染发生率差异无统计学意义(P>0.05),而与C组相比则显著降低(χ~2=5.316,P<0.01;χ~2=3.843,P<0.05)。结论与缩宫素相比,地诺前列酮栓用于足月胎膜早破孕妇促宫颈成熟效果更佳,引产更加安全有效,剖宫产率也显著降低。

Objective To investigate the clinical curative effect of premature rupture of membranes by Dinoprostone Suppositories.Methods From October 2015 to August 2016 in Shapingba District of Chongqing City Maternal and child health family planning service center from 150 cases with indications for labor induction of full-term pregnant women as the research object,including 100 cases of premature rupture of membranes,without membrane rupture in 50 cases(group B).Methods 100 cases of premature rupture of membranes were divided into A group and C group according to different treatment methods,each with 50 cases.A group and B group were induced using Dinoprostone Suppositories C group,the use of oxytocin.Comparison of 3 groups of pregnant women,pregnant women to complete the basic information;records of cervical maturity,the rate of vaginal delivery and cesarean section occurred;and statistics of pregnant women and neonatal puerperal infection.Results A group and B group of pregnant women completed cervical maturation rate were significantly higher than C group,the difference was statistically significant(χ~2=11.11,P<0.01);A,B two groups had no statistically significant differences in maternal vaginal delivery rate(P>0.05),but increased significantly compared with C group(χ~2=11.98,P<0.01;χ~2=6.25,P<0.05);A group and B group,the incidence rate of fetal distress was significantly lower than that in C group,the difference was statistically significant(χ~2=5.69,P<0.01);A,B two groups of pregnant women,the incidence rate of puerperal infection had no significant difference(P>0.05),and compared with the C group decreased significantly(χ~2=5.316,P<0.01;χ~2=3.843,P<0.05).Conclusion Compared with oxytocin,Dinoprostone Suppositories for premature rupture of membranes for cervical ripening and labor induction effect is better,safer and more effective,the rate of cesarean section was significantly lower.