沙丁胺醇联合布地奈德治疗支气管哮喘急性发作患者的疗效观察

Clinical observation of salbutamol combined with budesonide in the treatment of acute attack of bronchial asthma

目的探讨沙丁胺醇联合布地奈德治疗支气管哮喘急性发作患者的临床疗效。方法选取2015年8月至2016年8月揭西县妇幼保健院收治的支气管哮喘急性发作患者80例,随机分为A组和B组,各40例。B组患者采用沙丁胺醇治疗,A组患者在B组治疗基础上采用布地奈德治疗。比较A、B两组患者治疗后的总有效率、肺功能、不良反应发生率以及生命质量评分。结果 A组患者治疗的总有效率明显高于B组,差异有统计学意义(P<0.05);经过7 d的治疗,A组患者的用力肺活量(FVC)、第一秒用力呼气量(FEV1)和最大通气量(MVV)均明显高于B组,差异均有统计学意义(均P<0.05);A组患者物质生活、心理功能、社会功能以及躯体功能评分均明显高于B组,差异均有统计学意义(均P<0.05)。结论沙丁胺醇、布地奈德联合治疗支气管哮喘急性发作临床效果显著,可有效改善患者肺功能,提升生命质量,并且不良反应发生率极低。

Objective To investigate the clinical efficacy of salbutamol combined with budesonide in the treatment of acute attack of bronchial asthma.Methods 80 patients with acute episode of bronchial asthma were selected from August 2015 to August 2016 in Jiexi maternal and child health care hospital.They were randomly divided into A group and B group（n=40）.Patients in group B were treated with salbutamol,A group was treated with budesonide in the treatment of B group.The total effective rate,pulmonary function,adverse reaction rate and quality of life score were compared between the two groups of patients with A and B.Results The treatment of A patients with total efficiency was significantly higher than that of B,the difference was statistically significant （P〈0.05）;after 7 d treatment,A group were forced vital capacity（FVC）,forced expiratory volume in one second（FEV1） and maximal ventilatory volume（MVV） were significantly higher than that in B group,the differences were statistically significant（P〈0.05）;A group of material life,psychological function,social function and physical function scores were significantly higher than that in B group, the differences were statistically significant（P〈0.05）.Conclusion Salbutarnol and budesonide in the treatment of acute exacerbation of bronchial asthma clinical effect,can effectively improve the patient＇s lung function, improve the quality of life,and the incidence of adverse reactions is very low.